Animal Models
Oo TF and Burke RE. Animal Models of Induced Apoptotic death in the Substantia Nigra. In MM Mouradian (Ed), Methods in Molecular Medicine. Parkinson's Disease: Methods and Protocols, Humana Press, Inc., 2000.
This manuscript presents a detailed, step-by step guide to the methods we use in postnatal models for the induction of apoptosis in substantia nigra by excitotoxic striatal lesion and striatal 6-hydroxydopamine lesion.

Histological Methods
Oo TF and Burke RE. Histochemical Methods For The Detection Of Apoptosis In The Nervous System. In C.R. Gerfen (Ed), Current Protocols in Neuroscience, John Wiley and Sons, Inc, 2007.
This manuscript contains detailed methodology on how to perform immunoperoxidase staining, immunofluorescence double labeling and suppressed silver staining to detect apoptosis in tissue sections.